Impaired daily glucocorticoid rhythm in Per1 Brd mice
نویسندگان
چکیده
منابع مشابه
PER1 phosphorylation specifies feeding rhythm in mice.
Organization of circadian behavior, physiology, and metabolism is important for human health. An S662G mutation in hPER2 has been linked to familial advanced sleep-phase syndrome (FASPS). Although the paralogous phosphorylation site S714 in PER1 is conserved in mice, its specific function in circadian organization remains unknown. Here, we find that the PER1S714G mutation accelerates the molecu...
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The house mouse Mus musculus represents a valuable tool for the analysis and the understanding of the mammalian circadian oscillator. Forward and reverse genetics allowed the identification of clock components and the verification of their function within the circadian clockwork. In many cases unforeseen links were discovered between a particular circadian regulatory protein and various disease...
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ژورنال
عنوان ژورنال: Journal of Comparative Physiology A
سال: 2006
ISSN: 0340-7594,1432-1351
DOI: 10.1007/s00359-006-0114-9